This site runs the risk of being very musical comedy heavy at the moment. Apologies. We will cover other subjects!
However, for those people creating musical comedy, there are a couple of handy tools out there.
Vocal Remover – removes vocals from tracks, leaving you a stem vocal and the backing track.
Splitter.ai – is capable of splitting a track down into multiple stems, though it seems to do a great job of things like vocals, and then arbitrarily finds certain instruments and an “other” category
4k Video Downloader – enables you to grab video or sound direct out of YouTube (copyright permitting, of course).
Put together, these tools may enable you to produce content, or maybe even just prototype something to see how it sounds before creating a proper version of your own.